Increased inflammation has been associated with the development of depression, a disease that afflicts over 20 million adults in the United States. Our previous work in patients with depression has found that high levels of inflammation affect reward circuitry in the brain to lead to anhedonia, a core symptom of depression characterized by a lack of motivation. The proposed research will determine whether these inflammation- related changes in neurocircuitry are mediated by decreased dopamine, with the overarching goal of revealing brain biomarkers that can serve as novel targets for therapeutic strategies to reverse the effects of inflammation on dopamine signaling and symptoms of depression, particularly anhedonia. Click here to learn more about the study details.