We study interactions between the brain and the immune system, especially as they relate to the effects of inflammation on the development of psychiatric disorders including depression, anxiety disorders and schizophrenia. We also study the impact of inflammation on the brain in medically ill patients including patients with cancer. Special emphasis in our studies is placed on the effects of inflammation on neurotransmitter systems involving dopamine and glutamate as well as the integrity of local and regional brain networks. Finally, we are exploring a variety of treatment strategies that target the immune system to treat psychiatric disorders. By combining multiple frames of reference, we believe that novel approaches to human suffering can be achieved through strategies that address both brain and immune aspects of health and illness.
Anhedonia in depressed patients with high inflammation exhibit alterations in glucose metabolism including the energy inefficient glycolysis, Is anhedonia an adaptation to the energy demands of inflammation? Check out https://authors.elsevier.com/c/1bTuQ3AAzzTAEq.