Over one third of all depressed patients have a difficult time responding to antidepressant medication. One issue that plagues antidepressant response is the choice of the right antidepressant for the right person. In this study, we will test the hypothesis that a simple blood test of inflammation can predict whether a depressed patient will respond better to one antidepressant versus another. In particular, we will determine whether depressed patients with high inflammation respond better to bupropion than escitalopram. In addition, we will determine whether this effect is mediated by the impact of bupropion on reward circuits in the brain. For more information on this study please click here or if you are interested in participating in this study, please contact us.