The role of inflammation in depression: from evolutionary imperative to modern treatment target

Mounting evidence indicates that the immune system and the brain worked together to protect early humans in a hostile ancestral environment rife with pathogens and predators. In modern times, however, chronic activation of the immune system may adversely affect the brain to cause depression. The most recent advances in this area of research were published by our group in a recent review in Nature Reviews Immunology. Read our article on inflammation and depression.